Nuclear Receptors: From Structure to the Clinic

Nuclear Receptors: From Structure to the Clinic

2015 | 236 Pages | ISBN: 3319187287 | PDF | 7 MB

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity.
The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors. ?


Download:

http://longfiles.com/tjs1v61tlaww/Nuclear_Receptors_From_Structure_to_the_Clinic.pdf.html

[Fast Download] Nuclear Receptors: From Structure to the Clinic


Ebooks related to "Nuclear Receptors: From Structure to the Clinic" :
Cholecystitis
Chromium
Chlorine
Childbirth
Cholesteatoma
An Introductory Philosophy of Medicine: Humanizing Modern Medicine
Diagnosis and Treatment of Cancer (The Biology of Cancer)
Wintrobe's clinical hematology - 12th edition
Understanding Medical Education: Evidence, Theory and Practice
Foundations of Evidence-Based Medicine
Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.